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As well as fostering feelings of guilt, shame and anxiety around food, cyclical weight fluctuations can diminish your muscle mass, slow your metabolism and increase your risk of chronic health conditions like heart disease, diabetes and high blood pressure

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Retatrutide is investigated in research models of glucose homeostasis, lipid metabolism, body composition, energy expenditure, and appetite regulation

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Risk of bias/quality appraisal The Critical Appraisal Skills Program (CASP) was used to assess risk of bias (Critical appraisal skills programme 2026)